![mgd to cfs mgd to cfs](https://media.cheggcdn.com/study/6bf/6bf12cc7-c2d0-4342-a8fa-092b2c6715e8/image.png)
This calls for the ability to evaluate the severity of MGD with a more integrated system including the whole ocular surface morpho-functional unit to adjust treatment accordingly. Moreover, recent studies have emphasized that the pathophysiologic alterations caused by MGD will eventually impair the tear film and eventually the whole ocular surface as the disease progresses. Thus, MGD is commonly characterized by symptoms of eye irritation and typical changes of signs in the meibomian gland or the meibum, which is secreted to form a thin lipid layer to protect the tear film covering the ocular surface from evaporation. The International Workshop on MGD defined the disease to be chronic, diffuse abnormality of the meibomian glands, leading to morphological, and/or functional alterations. The relationship between the specific symptoms, signs, and IVCM results concerning whole ocular surface impairment could help elucidate MGD pathophysiology and benefit evaluation or treatment in the future.Ĭonsidered to be a major cause of dry eye syndrome, meibomian gland dysfunction (MGD) is one of the most common ocular disorders encountered in ophthalmic clinics with prevalence ranging from 3.5% to 70.0% worldwide, and has been found to be 69.3% in China.
![mgd to cfs mgd to cfs](https://cdn.numerade.com/ask_images/5b8676b25443406fbbc782b032b3150b.jpg)
The comprehensive grading scale was suitable for evaluating clinical manifestations in MGD of varying severity. MG score was correlated with nerve reflectivity ( r = 0.265, P < .05). Total symptom score was negatively correlated with nerve density ( r = –0.374, P < .05), while positively correlated with nerve reflectivity and dendritic cell density ( r = 0.332 and 0.288, respectively, P < .05). The mild MGD group showed higher nerve density ( P < .05). The severe MGD group showed worse MG expressibility, Meibum score, Meiboscore, MG score, and higher nerve reflectivity ( P < .05). The differences and correlations between symptoms, signs, and IVCM parameters were analyzed.ĭryness, foreign body sensation, asthenopia, and photophobia were the most common and severe symptoms in our patients.
![mgd to cfs mgd to cfs](https://static.cambridge.org/binary/version/id/urn:cambridge.org:id:binary:20180528101533964-0650:S0884291418001073:S0884291418001073_fig5g.jpeg)
In vivo confocal microscopy (IVCM) was performed to evaluate the corneal nerves and dendritic cells. Slit-lamp and keratography were used to assess the signs of ocular surface and meibomian gland (MG). Thirty-seven patients were diagnosed with mild, 19 with moderate, and 7 with severe MGD. Ten specific symptoms were evaluated each with a subjective score and total score was applied to grade the severity of MGD. This study aimed to propose a comprehensive grading scale to evaluate different clinical manifestations in patients with varying severity of meibomian gland dysfunction (MGD) and analyze the correlations between the parameters of ocular surface impairment in MGD.Ī total of 63 patients with MGD were enrolled.